Portrait of sickle cell warrior against red blood cells breaking apart to represent hemolysis in sickle cell diseasePortrait of sickle cell warrior against red blood cells breaking apart to represent hemolysis in sickle cell disease

For your patients with sickle cell disease1-5HEMOLYSIS IS QUIET.THE DAMAGE IS NOT.

Damage goes beyond VOCs.

Hemolysis is silently causing:

  • anemia
  • organ damage
  • early mortality

VOC=vaso-occlusive crisis.

Kyle

Living With Sickle Cell

Now is the time to learn more about hemolysis and its devastating impact in sickle cell disease.1-5

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References:

1. Xue J, Li XA. Therapeutics for sickle cell disease intravascular hemolysis. Front Physiol. 2024;15:1474569. doi:10.3389/fphys.2024.1474569 2. Xu JZ, Thein SL. Revisiting anemia in sickle cell disease and finding the balance with therapeutic approaches. Blood. 2022;139(20):3030-3039. doi:10.1182/blood.2021013873 3. Ballas SK, Kuypers FA, Gordeuk VR, Hankins JS, Thompson AA, Vichinsky E. Time to rethink haemoglobin threshold guidelines in sickle cell disease. Br J Haematol. 2021;195(4):518-522. doi:10.1111/bjh.17578 4. Kato GJ, Steinberg MH, Gladwin MT. Intravascular hemolysis and the pathophysiology of sickle cell disease. J Clin Invest. 2017;127(3):750-760. doi:10.1172/JCI89741 5. Ataga KI, Gordeuk VR, Agodoa I, Colby JA, Gittings K, Allen IE. Low hemoglobin increases risk for cerebrovascular disease, kidney disease, pulmonary vasculopathy, and mortality in sickle cell disease: a systematic literature review and meta-analysis. PLoS One. 2020;15(4):e0229959. doi:10.1371/journal.pone.0229959